Leslie Vail did have an issue with the Upgrade to 2010 R2. A clean install went fine but she’s looking for help with an upgrade issue.
Dynamics Confessor Blogspot: Upgrade to 2010 R2?
Install, Upgrade & AdminMicrosoft & the GP Ecosystem
Archived post from 2011. Dynamics GP and the links it points to have changed since; check current documentation before relying on version-specific steps.